Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 2075..2538 Replicon plasmid pJD1
Accession NZ_CP106810
Organism Neisseria gonorrhoeae strain 10708

Toxin (Protein)


Gene name VapD Uniprot ID Q51003
Locus tag OCL44_RS11835 Protein ID WP_003690225.1
Coordinates 2075..2353 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q51002
Locus tag OCL44_RS11840 Protein ID WP_003690223.1
Coordinates 2353..2538 (-) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCL44_RS11815 (OCL44_11815) 67..447 + 381 WP_014580441.1 MobC family plasmid mobilization relaxosome protein -
OCL44_RS11820 (OCL44_11820) 432..998 + 567 WP_241532367.1 relaxase/mobilization nuclease domain-containing protein -
OCL44_RS11825 (OCL44_11825) 1155..1796 + 642 WP_146711211.1 MbeB family mobilization protein -
OCL44_RS11830 (OCL44_11830) 1843..2097 + 255 WP_003690227.1 Cryptic plasmid protein A -
OCL44_RS11835 (OCL44_11835) 2075..2353 - 279 WP_003690225.1 endoribonuclease VapD Toxin
OCL44_RS11840 (OCL44_11840) 2353..2538 - 186 WP_003690223.1 DUF5397 family protein Antitoxin
OCL44_RS11845 (OCL44_11845) 2541..2786 - 246 WP_003690221.1 hypothetical protein -
OCL44_RS11850 (OCL44_11850) 2783..3025 - 243 WP_003690220.1 HTH domain-containing protein -
OCL44_RS11855 (OCL44_11855) 3029..3898 - 870 WP_260237151.1 replication initiation protein -
OCL44_RS11860 (OCL44_11860) 3981..4205 - 225 WP_025455920.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..4217 4217


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(2-60)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10473.89 Da        Isoelectric Point: 6.9726

>T259846 WP_003690225.1 NZ_CP106810:c2353-2075 [Neisseria gonorrhoeae]
MYAISFDLVVADTAQNHPKGISQAYADIGYTLRKFGFTRIQGSLYTCQNEDMANLFSAINELKALPWFPSSVRDIRAFRI
EQWSDFTSLVKS

Download         Length: 279 bp

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 6717.54 Da        Isoelectric Point: 4.2641

>AT259846 WP_003690223.1 NZ_CP106810:c2538-2353 [Neisseria gonorrhoeae]
MQTTIPTGSIRTFGDYGVMYIVGTPAEQLPDGDWLVNIELPESGEHTQYKLSHIVQDPKAA

Download         Length: 186 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H5FJI5

Antitoxin

Source ID Structure
AlphaFold DB Q51002

References