Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 1412..1875 Replicon plasmid pJD1
Accession NZ_CP106808
Organism Neisseria gonorrhoeae strain 10736

Toxin (Protein)


Gene name VapD Uniprot ID Q51003
Locus tag OCL42_RS11795 Protein ID WP_003690225.1
Coordinates 1597..1875 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q51002
Locus tag OCL42_RS11790 Protein ID WP_003690223.1
Coordinates 1412..1597 (+) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCL42_RS11775 (OCL42_11775) 52..921 + 870 WP_260237151.1 replication initiation protein -
OCL42_RS11780 (OCL42_11780) 925..1167 + 243 WP_003690220.1 HTH domain-containing protein -
OCL42_RS11785 (OCL42_11785) 1164..1409 + 246 WP_003690221.1 hypothetical protein -
OCL42_RS11790 (OCL42_11790) 1412..1597 + 186 WP_003690223.1 DUF5397 family protein Antitoxin
OCL42_RS11795 (OCL42_11795) 1597..1875 + 279 WP_003690225.1 endoribonuclease VapD Toxin
OCL42_RS11800 (OCL42_11800) 1853..2107 - 255 WP_003690227.1 Cryptic plasmid protein A -
OCL42_RS11805 (OCL42_11805) 2154..2795 - 642 WP_146711211.1 MbeB family mobilization protein -
OCL42_RS11810 (OCL42_11810) 2879..3508 - 630 WP_003696452.1 relaxase/mobilization nuclease domain-containing protein -
OCL42_RS11815 (OCL42_11815) 3493..3873 - 381 WP_014580441.1 MobC family plasmid mobilization relaxosome protein -
OCL42_RS11820 (OCL42_11820) 3952..4176 + 225 WP_025455920.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..4207 4207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(2-60)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10473.89 Da        Isoelectric Point: 6.9726

>T259843 WP_003690225.1 NZ_CP106808:1597-1875 [Neisseria gonorrhoeae]
MYAISFDLVVADTAQNHPKGISQAYADIGYTLRKFGFTRIQGSLYTCQNEDMANLFSAINELKALPWFPSSVRDIRAFRI
EQWSDFTSLVKS

Download         Length: 279 bp

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 6717.54 Da        Isoelectric Point: 4.2641

>AT259843 WP_003690223.1 NZ_CP106808:1412-1597 [Neisseria gonorrhoeae]
MQTTIPTGSIRTFGDYGVMYIVGTPAEQLPDGDWLVNIELPESGEHTQYKLSHIVQDPKAA

Download         Length: 186 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H5FJI5

Antitoxin

Source ID Structure
AlphaFold DB Q51002

References