Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 947962..948617 Replicon chromosome
Accession NZ_CP106805
Organism Neisseria gonorrhoeae strain 10743

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag OCL39_RS04810 Protein ID WP_003691083.1
Coordinates 947962..948381 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag OCL39_RS04815 Protein ID WP_003688410.1
Coordinates 948381..948617 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCL39_RS04790 (OCL39_04790) 943196..944737 - 1542 WP_003701286.1 MDR family MFS transporter -
OCL39_RS04795 (OCL39_04795) 944885..945664 + 780 WP_003688416.1 (Fe-S)-binding protein -
OCL39_RS04800 (OCL39_04800) 945661..946362 + 702 WP_003688414.1 lactate utilization protein C -
OCL39_RS04805 (OCL39_04805) 946359..947813 + 1455 WP_003701282.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
OCL39_RS04810 (OCL39_04810) 947962..948381 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
OCL39_RS04815 (OCL39_04815) 948381..948617 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
OCL39_RS04820 (OCL39_04820) 949065..949643 - 579 WP_003688041.1 IS3 family transposase -
OCL39_RS04825 (OCL39_04825) 949648..950049 - 402 WP_020997339.1 helix-turn-helix domain-containing protein -
OCL39_RS04830 (OCL39_04830) 950288..950674 + 387 Protein_940 transposase -
OCL39_RS04835 (OCL39_04835) 951057..951947 - 891 WP_003693285.1 succinate--CoA ligase subunit alpha -
OCL39_RS04840 (OCL39_04840) 951958..953124 - 1167 WP_003701280.1 ADP-forming succinate--CoA ligase subunit beta -
OCL39_RS04845 (OCL39_04845) 953196..953483 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T259838 WP_003691083.1 NZ_CP106805:c948381-947962 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT259838 WP_003688410.1 NZ_CP106805:c948617-948381 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References