Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1518941..1519596 Replicon chromosome
Accession NZ_CP106789
Organism Neisseria gonorrhoeae strain 10638

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag LLE37_RS07975 Protein ID WP_003691083.1
Coordinates 1518941..1519360 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag LLE37_RS07980 Protein ID WP_003688410.1
Coordinates 1519360..1519596 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLE37_RS07955 (LLE37_07955) 1514175..1515716 - 1542 WP_003691084.1 MDR family MFS transporter -
LLE37_RS07960 (LLE37_07960) 1515864..1516643 + 780 WP_003688416.1 (Fe-S)-binding protein -
LLE37_RS07965 (LLE37_07965) 1516640..1517341 + 702 WP_003688414.1 lactate utilization protein C -
LLE37_RS07970 (LLE37_07970) 1517338..1518792 + 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
LLE37_RS07975 (LLE37_07975) 1518941..1519360 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
LLE37_RS07980 (LLE37_07980) 1519360..1519596 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
LLE37_RS07985 (LLE37_07985) 1520043..1520621 - 579 WP_003697246.1 IS3 family transposase -
LLE37_RS07990 (LLE37_07990) 1520626..1521027 - 402 WP_020996834.1 helix-turn-helix domain-containing protein -
LLE37_RS07995 (LLE37_07995) 1521266..1521652 + 387 Protein_1553 transposase -
LLE37_RS08000 (LLE37_08000) 1522035..1522925 - 891 WP_229930257.1 succinate--CoA ligase subunit alpha -
LLE37_RS08005 (LLE37_08005) 1522936..1524102 - 1167 WP_003699872.1 ADP-forming succinate--CoA ligase subunit beta -
LLE37_RS08010 (LLE37_08010) 1524174..1524461 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T259830 WP_003691083.1 NZ_CP106789:c1519360-1518941 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT259830 WP_003688410.1 NZ_CP106789:c1519596-1519360 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References