Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 479152..479770 Replicon chromosome
Accession NC_016822
Organism Shigella sonnei 53G

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag SSON53G_RS02370 Protein ID WP_001291435.1
Coordinates 479152..479370 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag SSON53G_RS02375 Protein ID WP_000344800.1
Coordinates 479396..479770 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSON53G_RS02340 (474444) 474444..475016 + 573 WP_000779812.1 YbaY family lipoprotein -
SSON53G_RS02345 (475047) 475047..475358 - 312 WP_000409911.1 MGMT family protein -
SSON53G_RS02350 (475737) 475737..476090 + 354 WP_000878140.1 DUF1428 domain-containing protein -
SSON53G_RS02355 (476132) 476132..477680 - 1549 Protein_443 cyclic-guanylate-specific phosphodiesterase PdeB -
SSON53G_RS02360 (477844) 477844..478314 - 471 WP_000136192.1 YlaC family protein -
SSON53G_RS02365 (478430) 478430..478981 - 552 WP_000102564.1 maltose O-acetyltransferase -
SSON53G_RS02370 (479152) 479152..479370 - 219 WP_001291435.1 HHA domain-containing protein Toxin
SSON53G_RS02375 (479396) 479396..479770 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
SSON53G_RS02380 (480316) 480316..483465 - 3150 WP_001132464.1 efflux RND transporter permease AcrB -
SSON53G_RS02385 (483488) 483488..484681 - 1194 WP_011310152.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T25983 WP_001291435.1 NC_016822:c479370-479152 [Shigella sonnei 53G]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T25983 NC_016822:c479370-479152 [Shigella sonnei 53G]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT25983 WP_000344800.1 NC_016822:c479770-479396 [Shigella sonnei 53G]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT25983 NC_016822:c479770-479396 [Shigella sonnei 53G]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References