Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 77741..78266 Replicon plasmid pKP1161-1
Accession NZ_CP106787
Organism Klebsiella pneumoniae strain KP1161

Toxin (Protein)


Gene name ccdB Uniprot ID A0A6S4YF27
Locus tag N9H76_RS26390 Protein ID WP_025714517.1
Coordinates 77741..78046 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID W8V2V6
Locus tag N9H76_RS26395 Protein ID WP_001568025.1
Coordinates 78048..78266 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N9H76_RS26360 (N9H76_26360) 73404..74030 + 627 WP_004197649.1 ParA family plasmid-partitioning AAA ATPase -
N9H76_RS26365 (N9H76_26365) 74027..74329 + 303 WP_071571079.1 hypothetical protein -
N9H76_RS26370 (N9H76_26370) 74817..75611 - 795 WP_004197635.1 site-specific integrase -
N9H76_RS26375 (N9H76_26375) 75809..76825 - 1017 WP_017899884.1 hypothetical protein -
N9H76_RS26380 (N9H76_26380) 76836..77150 - 315 WP_053389906.1 hypothetical protein -
N9H76_RS26385 (N9H76_26385) 77177..77572 - 396 WP_017899885.1 hypothetical protein -
N9H76_RS26390 (N9H76_26390) 77741..78046 - 306 WP_025714517.1 type II toxin-antitoxin system toxin CcdB Toxin
N9H76_RS26395 (N9H76_26395) 78048..78266 - 219 WP_001568025.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
N9H76_RS26400 (N9H76_26400) 78846..79415 + 570 WP_016162066.1 hypothetical protein -
N9H76_RS26405 (N9H76_26405) 79556..80584 + 1029 WP_001568023.1 Abi family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid qnrB4 / blaDHA-1 / sul1 - 1..115363 115363


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11562.25 Da        Isoelectric Point: 5.6906

>T259829 WP_025714517.1 NZ_CP106787:c78046-77741 [Klebsiella pneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSCELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8392.34 Da        Isoelectric Point: 4.7405

>AT259829 WP_001568025.1 NZ_CP106787:c78266-78048 [Klebsiella pneumoniae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6S4YF27

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZZP8

References