Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5232038..5232663 Replicon chromosome
Accession NZ_CP106786
Organism Klebsiella pneumoniae strain KP1161

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag N9H76_RS25520 Protein ID WP_002882817.1
Coordinates 5232038..5232421 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag N9H76_RS25525 Protein ID WP_075210489.1
Coordinates 5232421..5232663 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N9H76_RS25505 (N9H76_25505) 5229403..5230306 + 904 Protein_4983 formate dehydrogenase subunit beta -
N9H76_RS25510 (N9H76_25510) 5230303..5230938 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
N9H76_RS25515 (N9H76_25515) 5230935..5231864 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
N9H76_RS25520 (N9H76_25520) 5232038..5232421 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
N9H76_RS25525 (N9H76_25525) 5232421..5232663 - 243 WP_075210489.1 CopG family transcriptional regulator Antitoxin
N9H76_RS25530 (N9H76_25530) 5232868..5233785 + 918 WP_004181612.1 alpha/beta hydrolase -
N9H76_RS25535 (N9H76_25535) 5233799..5234740 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
N9H76_RS25540 (N9H76_25540) 5234785..5235222 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
N9H76_RS25545 (N9H76_25545) 5235219..5236079 - 861 WP_023280688.1 virulence factor BrkB family protein -
N9H76_RS25550 (N9H76_25550) 5236073..5236672 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(17-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T259828 WP_002882817.1 NZ_CP106786:c5232421-5232038 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9539.77 Da        Isoelectric Point: 4.3509

>AT259828 WP_075210489.1 NZ_CP106786:c5232663-5232421 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDAIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure

References