Detailed information of TA system TA259827

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4913878..4915559
• Replicon: chromosome
• Accession: NZ_CP106786
• Organism: Klebsiella pneumoniae strain KP1161

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: J2XCI1
• Locus tag: N9H76_RS24050
• Protein ID: WP_004146663.1
• Coordinates: 4913878..4914795 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: N9H76_RS24055
• Protein ID: WP_004177809.1
• Coordinates: 4914801..4915559 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
N9H76_RS24030 (N9H76_24030)	4909184..4910704	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
N9H76_RS24035 (N9H76_24035)	4910701..4911699	+	999	WP_002885172.1	ribose ABC transporter permease	-
N9H76_RS24040 (N9H76_24040)	4911730..4912671	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
N9H76_RS24045 (N9H76_24045)	4912746..4913753	+	1008	WP_004221949.1	carbohydrate kinase family protein	-
N9H76_RS24050 (N9H76_24050)	4913878..4914795	-	918	WP_004146663.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
N9H76_RS24055 (N9H76_24055)	4914801..4915559	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
N9H76_RS24060 (N9H76_24060)	4915645..4916373	-	729	WP_023159071.1	response regulator transcription factor	-
N9H76_RS24065 (N9H76_24065)	4916646..4918793	+	2148	WP_077598939.1	formate dehydrogenase subunit alpha	-
N9H76_RS24070 (N9H76_24070)	4919023..4919709	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34659.10 Da
• Isoelectric Point: 5.4707

>T259827 WP_004146663.1 NZ_CP106786:c4914795-4913878 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT259827 WP_004177809.1 NZ_CP106786:c4915559-4914801 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: J2XCI1

Antitoxin

• AlphaFold DB: A6TH05