Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4782802..4783318 Replicon chromosome
Accession NZ_CP106786
Organism Klebsiella pneumoniae strain KP1161

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag N9H76_RS23435 Protein ID WP_021469513.1
Coordinates 4783034..4783318 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag N9H76_RS23430 Protein ID WP_002886901.1
Coordinates 4782802..4783044 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N9H76_RS23415 (N9H76_23415) 4778830..4779570 + 741 WP_032412667.1 KDGP aldolase family protein -
N9H76_RS23420 (N9H76_23420) 4779637..4780791 + 1155 WP_002886900.1 lactonase family protein -
N9H76_RS23425 (N9H76_23425) 4780814..4782724 + 1911 WP_004152270.1 PRD domain-containing protein -
N9H76_RS23430 (N9H76_23430) 4782802..4783044 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N9H76_RS23435 (N9H76_23435) 4783034..4783318 + 285 WP_021469513.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N9H76_RS23440 (N9H76_23440) 4783322..4783786 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
N9H76_RS23445 (N9H76_23445) 4784035..4786173 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
N9H76_RS23450 (N9H76_23450) 4786530..4787273 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
N9H76_RS23455 (N9H76_23455) 4787276..4787449 - 174 WP_004222159.1 hypothetical protein -
N9H76_RS23460 (N9H76_23460) 4787579..4787842 + 264 WP_004152271.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11083.95 Da        Isoelectric Point: 10.4962

>T259826 WP_021469513.1 NZ_CP106786:4783034-4783318 [Klebsiella pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT259826 WP_002886901.1 NZ_CP106786:4782802-4783044 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References