Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4660602..4661412 Replicon chromosome
Accession NZ_CP106786
Organism Klebsiella pneumoniae strain KP1161

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag N9H76_RS22805 Protein ID WP_004178461.1
Coordinates 4660602..4661135 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag N9H76_RS22810 Protein ID WP_002887278.1
Coordinates 4661146..4661412 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N9H76_RS22800 (N9H76_22800) 4659433..4660554 + 1122 WP_023280822.1 cupin domain-containing protein -
N9H76_RS22805 (N9H76_22805) 4660602..4661135 - 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
N9H76_RS22810 (N9H76_22810) 4661146..4661412 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
N9H76_RS22815 (N9H76_22815) 4661515..4662948 - 1434 WP_023280821.1 Cu(+)/Ag(+) sensor histidine kinase -
N9H76_RS22820 (N9H76_22820) 4662938..4663621 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
N9H76_RS22825 (N9H76_22825) 4663794..4665179 + 1386 WP_032412712.1 efflux transporter outer membrane subunit -
N9H76_RS22830 (N9H76_22830) 4665197..4665541 + 345 WP_021441118.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T259825 WP_004178461.1 NZ_CP106786:c4661135-4660602 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT259825 WP_002887278.1 NZ_CP106786:c4661412-4661146 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References