Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2816248..2817836 Replicon chromosome
Accession NZ_CP106786
Organism Klebsiella pneumoniae strain KP1161

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag N9H76_RS13950 Protein ID WP_004199851.1
Coordinates 2816248..2817570 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag N9H76_RS13955 Protein ID WP_002904790.1
Coordinates 2817570..2817836 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N9H76_RS13935 (N9H76_13935) 2811496..2813814 + 2319 WP_263087887.1 fimbria/pilus outer membrane usher protein -
N9H76_RS13940 (N9H76_13940) 2813802..2814806 + 1005 WP_023286423.1 fimbrial protein -
N9H76_RS13945 (N9H76_13945) 2814939..2816231 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
N9H76_RS13950 (N9H76_13950) 2816248..2817570 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
N9H76_RS13955 (N9H76_13955) 2817570..2817836 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
N9H76_RS13960 (N9H76_13960) 2818101..2818427 - 327 WP_002904788.1 hydroxyisourate hydrolase -
N9H76_RS13965 (N9H76_13965) 2818424..2818924 - 501 WP_023286422.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
N9H76_RS13970 (N9H76_13970) 2818902..2820281 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
N9H76_RS13975 (N9H76_13975) 2820627..2821781 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
N9H76_RS13980 (N9H76_13980) 2821762..2822685 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T259822 WP_004199851.1 NZ_CP106786:c2817570-2816248 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT259822 WP_002904790.1 NZ_CP106786:c2817836-2817570 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References