Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 1014103..1015013 Replicon chromosome
Accession NZ_CP106786
Organism Klebsiella pneumoniae strain KP1161

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag N9H76_RS05140 Protein ID WP_004026354.1
Coordinates 1014103..1014573 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag N9H76_RS05145 Protein ID WP_114271262.1
Coordinates 1014570..1015013 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N9H76_RS05115 (N9H76_05115) 1009218..1009616 - 399 WP_004212796.1 H-NS family nucleoid-associated regulatory protein -
N9H76_RS05120 (N9H76_05120) 1009953..1010447 - 495 WP_004212794.1 thermonuclease family protein -
N9H76_RS05125 (N9H76_05125) 1010625..1010891 + 267 WP_223175074.1 DUF1173 family protein -
N9H76_RS05130 (N9H76_05130) 1010924..1011574 + 651 WP_068893702.1 DUF1173 family protein -
N9H76_RS05140 (N9H76_05140) 1014103..1014573 - 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
N9H76_RS05145 (N9H76_05145) 1014570..1015013 - 444 WP_114271262.1 DUF2384 domain-containing protein Antitoxin
N9H76_RS05150 (N9H76_05150) 1015114..1015617 - 504 Protein_1015 DUF4113 domain-containing protein -
N9H76_RS05155 (N9H76_05155) 1015715..1015936 - 222 WP_004213643.1 DUF2188 domain-containing protein -
N9H76_RS05160 (N9H76_05160) 1016117..1016236 - 120 Protein_1017 Fe3+-citrate ABC transporter substrate-binding protein -
N9H76_RS05165 (N9H76_05165) 1016311..1018437 - 2127 WP_004213640.1 TonB-dependent Fe(3+) dicitrate receptor FecA -
N9H76_RS05170 (N9H76_05170) 1018524..1019477 - 954 Protein_1019 fec operon regulator FecR -
N9H76_RS05175 (N9H76_05175) 1019474..1019995 - 522 WP_004213635.1 ferric citrate uptake sigma factor FecI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1012960..1013463 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(93-144)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T259816 WP_004026354.1 NZ_CP106786:c1014573-1014103 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16452.75 Da        Isoelectric Point: 9.9958

>AT259816 WP_114271262.1 NZ_CP106786:c1015013-1014570 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDQAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure

References