Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 791756..792666 Replicon chromosome
Accession NZ_CP106786
Organism Klebsiella pneumoniae strain KP1161

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag N9H76_RS03925 Protein ID WP_004026354.1
Coordinates 791756..792226 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag N9H76_RS03930 Protein ID WP_114271262.1
Coordinates 792223..792666 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N9H76_RS03900 (N9H76_03900) 786871..787269 - 399 WP_004212796.1 H-NS family nucleoid-associated regulatory protein -
N9H76_RS03905 (N9H76_03905) 787606..788100 - 495 WP_004212794.1 thermonuclease family protein -
N9H76_RS03910 (N9H76_03910) 788278..788544 + 267 WP_223175074.1 DUF1173 family protein -
N9H76_RS03915 (N9H76_03915) 788577..789227 + 651 WP_068893702.1 DUF1173 family protein -
N9H76_RS03925 (N9H76_03925) 791756..792226 - 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
N9H76_RS03930 (N9H76_03930) 792223..792666 - 444 WP_114271262.1 DUF2384 domain-containing protein Antitoxin
N9H76_RS03935 (N9H76_03935) 792767..793270 - 504 Protein_772 DUF4113 domain-containing protein -
N9H76_RS03940 (N9H76_03940) 793368..793589 - 222 WP_004213643.1 DUF2188 domain-containing protein -
N9H76_RS03945 (N9H76_03945) 793770..793889 - 120 Protein_774 Fe3+-citrate ABC transporter substrate-binding protein -
N9H76_RS03950 (N9H76_03950) 793964..796090 - 2127 WP_004213640.1 TonB-dependent Fe(3+) dicitrate receptor FecA -
N9H76_RS03955 (N9H76_03955) 796177..797130 - 954 Protein_776 fec operon regulator FecR -
N9H76_RS03960 (N9H76_03960) 797127..797648 - 522 WP_004213635.1 ferric citrate uptake sigma factor FecI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - rfaE / iroB / iroC / iroD / iroN / rmpA 654970..880466 225496
- flank IS/Tn - - 790613..791116 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(93-144)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T259814 WP_004026354.1 NZ_CP106786:c792226-791756 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16452.75 Da        Isoelectric Point: 9.9958

>AT259814 WP_114271262.1 NZ_CP106786:c792666-792223 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDQAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure

References