Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5234453..5235080 Replicon chromosome
Accession NZ_CP106785
Organism Pseudomonas tohonis strain G5.110

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag N9L84_RS24005 Protein ID WP_263151077.1
Coordinates 5234898..5235080 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N9L84_RS24000 Protein ID WP_263151076.1
Coordinates 5234453..5234860 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N9L84_RS23990 (N9L84_23990) 5232289..5233296 + 1008 WP_263151074.1 nucleoid-associated protein YejK -
N9L84_RS23995 (N9L84_23995) 5233355..5234290 - 936 WP_263151075.1 glutathione S-transferase family protein -
N9L84_RS24000 (N9L84_24000) 5234453..5234860 - 408 WP_263151076.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N9L84_RS24005 (N9L84_24005) 5234898..5235080 - 183 WP_263151077.1 type II toxin-antitoxin system HicA family toxin Toxin
N9L84_RS24010 (N9L84_24010) 5235223..5235531 - 309 WP_263151078.1 GIY-YIG nuclease family protein -
N9L84_RS24015 (N9L84_24015) 5235528..5236226 - 699 WP_263151079.1 glutathione S-transferase family protein -
N9L84_RS24020 (N9L84_24020) 5236308..5236778 - 471 WP_263151080.1 nuclear transport factor 2 family protein -
N9L84_RS24025 (N9L84_24025) 5236895..5237848 + 954 WP_263151081.1 helix-turn-helix domain-containing protein -
N9L84_RS24030 (N9L84_24030) 5238302..5239063 - 762 WP_111263764.1 amino acid ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6841.90 Da        Isoelectric Point: 10.5627

>T259811 WP_263151077.1 NZ_CP106785:c5235080-5234898 [Pseudomonas tohonis]
MRSREVIEKIKEDGWYEVDVKGSHHQFKHPSKPGRVTVPHPRSDLPIGTVRSILKQAGLL

Download         Length: 183 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14523.38 Da        Isoelectric Point: 4.3759

>AT259811 WP_263151076.1 NZ_CP106785:c5234860-5234453 [Pseudomonas tohonis]
MKFPIVLHKDPDSDYGVTVPDVPGCFSAGATVAEALENVKEALALHFEGLVADGETLPQAQQIDVYIGNPDFAGGVWAVV
EFDVTPYLGKAVRFNATLPENLLRRIDERVGKDARYASRSGFLATAALRELSDAS

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References