Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4621291..4622549 Replicon chromosome
Accession NZ_CP106784
Organism Pseudomonas aeruginosa strain NY5085

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag N9J97_RS21545 Protein ID WP_003086331.1
Coordinates 4621291..4622046 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag N9J97_RS21550 Protein ID WP_003086329.1
Coordinates 4622181..4622549 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N9J97_RS21535 (N9J97_21535) 4616461..4619004 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
N9J97_RS21540 (N9J97_21540) 4619159..4620520 - 1362 WP_003081943.1 DNA recombination protein RmuC -
N9J97_RS21545 (N9J97_21545) 4621291..4622046 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
N9J97_RS21550 (N9J97_21550) 4622181..4622549 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
N9J97_RS21555 (N9J97_21555) 4622622..4623908 - 1287 WP_070698512.1 FAD-binding oxidoreductase -
N9J97_RS21560 (N9J97_21560) 4623964..4625553 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
N9J97_RS21565 (N9J97_21565) 4625632..4626108 + 477 WP_019372052.1 elongation factor GreAB -
N9J97_RS21570 (N9J97_21570) 4626111..4626386 - 276 WP_010792073.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T259802 WP_003086331.1 NZ_CP106784:c4622046-4621291 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT259802 WP_003086329.1 NZ_CP106784:c4622549-4622181 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References