Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3696268..3697489 Replicon chromosome
Accession NZ_CP106784
Organism Pseudomonas aeruginosa strain NY5085

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag N9J97_RS17220 Protein ID WP_003102740.1
Coordinates 3696911..3697489 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag N9J97_RS17215 Protein ID WP_003088112.1
Coordinates 3696268..3696822 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N9J97_RS17190 (N9J97_17190) 3691836..3692387 + 552 WP_003102727.1 XRE family transcriptional regulator -
N9J97_RS17195 (N9J97_17195) 3692384..3692782 - 399 WP_023082958.1 NADH-quinone oxidoreductase subunit A -
N9J97_RS17200 (N9J97_17200) 3692795..3693118 - 324 WP_003102734.1 multidrug efflux SMR transporter -
N9J97_RS17205 (N9J97_17205) 3693449..3693910 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
N9J97_RS17210 (N9J97_17210) 3693915..3696110 + 2196 WP_004349295.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
N9J97_RS17215 (N9J97_17215) 3696268..3696822 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
N9J97_RS17220 (N9J97_17220) 3696911..3697489 + 579 WP_003102740.1 HD domain-containing protein Toxin
N9J97_RS17225 (N9J97_17225) 3697598..3698785 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
N9J97_RS17230 (N9J97_17230) 3698775..3700946 - 2172 WP_009876279.1 type I secretion system permease/ATPase -
N9J97_RS17235 (N9J97_17235) 3700936..3702213 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T259801 WP_003102740.1 NZ_CP106784:3696911-3697489 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT259801 WP_003088112.1 NZ_CP106784:3696268-3696822 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References