259800

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2757965..2759007 Replicon chromosome
Accession NZ_CP106784
Organism Pseudomonas aeruginosa strain NY5085

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag N9J97_RS13260 Protein ID WP_003153636.1
Coordinates 2758432..2759007 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag N9J97_RS13255 Protein ID WP_003050245.1
Coordinates 2757965..2758435 (+) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N9J97_RS13220 (N9J97_13220) 2753344..2754762 - 1419 WP_004350605.1 TIGR03752 family integrating conjugative element protein -
N9J97_RS13225 (N9J97_13225) 2754752..2755663 - 912 WP_004350604.1 TIGR03749 family integrating conjugative element protein -
N9J97_RS13230 (N9J97_13230) 2755660..2756352 - 693 WP_012614071.1 TIGR03746 family integrating conjugative element protein -
N9J97_RS13235 (N9J97_13235) 2756349..2756759 - 411 WP_003821108.1 TIGR03750 family conjugal transfer protein -
N9J97_RS13240 (N9J97_13240) 2756772..2757131 - 360 WP_003153634.1 TIGR03745 family integrating conjugative element membrane protein -
N9J97_RS13245 (N9J97_13245) 2757148..2757381 - 234 WP_003050225.1 TIGR03758 family integrating conjugative element protein -
N9J97_RS13250 (N9J97_13250) 2757378..2757761 - 384 WP_003090167.1 RAQPRD family integrative conjugative element protein -
N9J97_RS13255 (N9J97_13255) 2757965..2758435 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
N9J97_RS13260 (N9J97_13260) 2758432..2759007 + 576 WP_003153636.1 PIN domain-containing protein Toxin
N9J97_RS13265 (N9J97_13265) 2759025..2759939 + 915 WP_003050256.1 AAA family ATPase -
N9J97_RS13270 (N9J97_13270) 2759936..2760406 + 471 WP_003153638.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
N9J97_RS13275 (N9J97_13275) 2760403..2760903 + 501 WP_003090159.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
N9J97_RS13280 (N9J97_13280) 2760903..2761805 + 903 WP_003153640.1 CBASS oligonucleotide cyclase -
N9J97_RS13285 (N9J97_13285) 2761844..2762569 + 726 WP_003050273.1 CBASS effector endonuclease NucC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2694593..2812312 117719


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T259800 WP_003153636.1 NZ_CP106784:2758432-2759007 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT259800 WP_003050245.1 NZ_CP106784:2757965-2758435 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References