Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1930559..1932067 Replicon chromosome
Accession NZ_CP106784
Organism Pseudomonas aeruginosa strain NY5085

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag N9J97_RS09145 Protein ID WP_003119682.1
Coordinates 1930559..1931146 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9HYX2
Locus tag N9J97_RS09150 Protein ID WP_003115566.1
Coordinates 1931213..1932067 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N9J97_RS09140 (N9J97_09140) 1926814..1930293 - 3480 WP_089034972.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
N9J97_RS09145 (N9J97_09145) 1930559..1931146 + 588 WP_003119682.1 GNAT family protein Toxin
N9J97_RS09150 (N9J97_09150) 1931213..1932067 + 855 WP_003115566.1 AraC family transcriptional regulator Antitoxin
N9J97_RS09155 (N9J97_09155) 1932164..1934329 + 2166 WP_003091606.1 TonB-dependent receptor family protein -
N9J97_RS09160 (N9J97_09160) 1934504..1936378 + 1875 WP_003117607.1 MFS transporter -
N9J97_RS09165 (N9J97_09165) 1936439..1936648 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T259799 WP_003119682.1 NZ_CP106784:1930559-1931146 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31933.23 Da        Isoelectric Point: 7.3276

>AT259799 WP_003115566.1 NZ_CP106784:1931213-1932067 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHADSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB Q9HYX2

References