Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 141056..141561 Replicon chromosome
Accession NZ_CP106784
Organism Pseudomonas aeruginosa strain NY5085

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag N9J97_RS00645 Protein ID WP_003121619.1
Coordinates 141056..141337 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag N9J97_RS00650 Protein ID WP_003112628.1
Coordinates 141334..141561 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N9J97_RS00620 (N9J97_00620) 136307..137656 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
N9J97_RS00625 (N9J97_00625) 137705..138391 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
N9J97_RS00630 (N9J97_00630) 138492..139226 + 735 WP_003101224.1 GntR family transcriptional regulator -
N9J97_RS00635 (N9J97_00635) 139406..139816 + 411 WP_003101225.1 aegerolysin family protein -
N9J97_RS00640 (N9J97_00640) 139848..140756 - 909 WP_003083769.1 LysR family transcriptional regulator -
N9J97_RS00645 (N9J97_00645) 141056..141337 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
N9J97_RS00650 (N9J97_00650) 141334..141561 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
N9J97_RS00655 (N9J97_00655) 141737..142357 - 621 WP_003101226.1 hypothetical protein -
N9J97_RS00660 (N9J97_00660) 142458..142958 + 501 WP_003112629.1 LEA type 2 family protein -
N9J97_RS00665 (N9J97_00665) 143031..143372 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
N9J97_RS00670 (N9J97_00670) 143454..144881 - 1428 WP_003083784.1 GABA permease -
N9J97_RS00675 (N9J97_00675) 145050..146543 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T259797 WP_003121619.1 NZ_CP106784:c141337-141056 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT259797 WP_003112628.1 NZ_CP106784:c141561-141334 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References