259795

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 951141..951796 Replicon chromosome
Accession NZ_CP106782
Organism Neisseria gonorrhoeae strain 10795

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag LLE27_RS04895 Protein ID WP_003691083.1
Coordinates 951141..951560 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag LLE27_RS04900 Protein ID WP_003688410.1
Coordinates 951560..951796 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLE27_RS04875 (LLE27_04875) 946375..947916 - 1542 WP_003691084.1 MDR family MFS transporter -
LLE27_RS04880 (LLE27_04880) 948064..948843 + 780 WP_003688416.1 (Fe-S)-binding protein -
LLE27_RS04885 (LLE27_04885) 948840..949541 + 702 WP_003688414.1 lactate utilization protein C -
LLE27_RS04890 (LLE27_04890) 949538..950992 + 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
LLE27_RS04895 (LLE27_04895) 951141..951560 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
LLE27_RS04900 (LLE27_04900) 951560..951796 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
LLE27_RS04905 (LLE27_04905) 952243..952821 - 579 WP_003697246.1 IS3 family transposase -
LLE27_RS04910 (LLE27_04910) 952826..953116 - 291 WP_047917062.1 helix-turn-helix domain-containing protein -
LLE27_RS04915 (LLE27_04915) 953466..953852 + 387 Protein_965 transposase -
LLE27_RS04920 (LLE27_04920) 954235..955125 - 891 WP_229930257.1 succinate--CoA ligase subunit alpha -
LLE27_RS04925 (LLE27_04925) 955136..956302 - 1167 WP_003699872.1 ADP-forming succinate--CoA ligase subunit beta -
LLE27_RS04930 (LLE27_04930) 956374..956661 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T259795 WP_003691083.1 NZ_CP106782:c951560-951141 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT259795 WP_003688410.1 NZ_CP106782:c951796-951560 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
AlphaFold DB Q5F881

References