Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 951930..952585 Replicon chromosome
Accession NZ_CP106780
Organism Neisseria gonorrhoeae strain 10794

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag LLE29_RS04940 Protein ID WP_003691083.1
Coordinates 951930..952349 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag LLE29_RS04945 Protein ID WP_003688410.1
Coordinates 952349..952585 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLE29_RS04920 (LLE29_04920) 947164..948705 - 1542 WP_003691084.1 MDR family MFS transporter -
LLE29_RS04925 (LLE29_04925) 948853..949632 + 780 WP_003688416.1 (Fe-S)-binding protein -
LLE29_RS04930 (LLE29_04930) 949629..950330 + 702 WP_003688414.1 lactate utilization protein C -
LLE29_RS04935 (LLE29_04935) 950327..951781 + 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
LLE29_RS04940 (LLE29_04940) 951930..952349 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
LLE29_RS04945 (LLE29_04945) 952349..952585 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
LLE29_RS04950 (LLE29_04950) 953032..953610 - 579 WP_003697246.1 IS3 family transposase -
LLE29_RS04955 (LLE29_04955) 953615..953905 - 291 WP_047917062.1 helix-turn-helix domain-containing protein -
LLE29_RS04960 (LLE29_04960) 954255..954641 + 387 Protein_974 transposase -
LLE29_RS04965 (LLE29_04965) 955024..955914 - 891 WP_229930257.1 succinate--CoA ligase subunit alpha -
LLE29_RS04970 (LLE29_04970) 955925..957091 - 1167 WP_003699872.1 ADP-forming succinate--CoA ligase subunit beta -
LLE29_RS04975 (LLE29_04975) 957163..957450 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T259793 WP_003691083.1 NZ_CP106780:c952349-951930 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT259793 WP_003688410.1 NZ_CP106780:c952585-952349 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References