Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta(toxin) |
| Location | 17712..19363 | Replicon | plasmid pConjugative |
| Accession | NZ_CP106778 | ||
| Organism | Neisseria gonorrhoeae strain 10727 | ||
Toxin (Protein)
| Gene name | ng_zeta1 | Uniprot ID | - |
| Locus tag | LLE38_RS11695 | Protein ID | WP_033911112.1 |
| Coordinates | 18158..19363 (-) | Length | 402 a.a. |
Antitoxin (Protein)
| Gene name | ng_epsilon1 | Uniprot ID | D5K9G8 |
| Locus tag | LLE38_RS11690 | Protein ID | WP_003701903.1 |
| Coordinates | 17712..18143 (-) | Length | 144 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LLE38_RS11660 (LLE38_11665) | 12821..13597 | + | 777 | WP_003701891.1 | P-type conjugative transfer protein TrbJ | - |
| LLE38_RS11665 (LLE38_11670) | 13811..15439 | + | 1629 | WP_047920931.1 | P-type conjugative transfer protein TrbL | - |
| LLE38_RS11670 (LLE38_11675) | 15432..16004 | + | 573 | WP_226888038.1 | TrbM/KikA/MpfK family conjugal transfer protein | - |
| LLE38_RS11675 (LLE38_11680) | 16004..16603 | + | 600 | WP_003701898.1 | TrbN protein | - |
| LLE38_RS11680 (LLE38_11685) | 16706..16996 | + | 291 | WP_003701899.1 | virulence factor | - |
| LLE38_RS11685 (LLE38_11690) | 17106..17660 | - | 555 | WP_003701901.1 | recombinase family protein | - |
| LLE38_RS11690 (LLE38_11695) | 17712..18143 | - | 432 | WP_003701903.1 | hypothetical protein | Antitoxin |
| LLE38_RS11695 (LLE38_11700) | 18158..19363 | - | 1206 | WP_033911112.1 | zeta toxin family protein | Toxin |
| LLE38_RS11700 (LLE38_11705) | 19370..19555 | - | 186 | WP_014580058.1 | hypothetical protein | - |
| LLE38_RS11705 (LLE38_11710) | 19589..20797 | - | 1209 | WP_014580057.1 | zeta toxin family protein | - |
| LLE38_RS11710 (LLE38_11715) | 20794..21042 | - | 249 | WP_014580056.1 | hypothetical protein | - |
| LLE38_RS11715 (LLE38_11720) | 21527..22000 | + | 474 | WP_206692149.1 | hypothetical protein | - |
| LLE38_RS11720 (LLE38_11725) | 22152..23048 | - | 897 | WP_003701917.1 | hypothetical protein | - |
| LLE38_RS11725 (LLE38_11730) | 23052..23393 | - | 342 | WP_013085576.1 | hypothetical protein | - |
| LLE38_RS11730 (LLE38_11735) | 23407..23721 | - | 315 | WP_082295984.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..39245 | 39245 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 402 a.a. Molecular weight: 44747.59 Da Isoelectric Point: 7.2930
>T259792 WP_033911112.1 NZ_CP106778:c19363-18158 [Neisseria gonorrhoeae]
MVKLSSDINLRDFGNNEYLSSVQDEAIRFATEQTDEILSLYSQHADTEGGRYVCADTFKELFPAFENKEDRATVNNAIHN
SAAVLSSTQFDEVLKRDEPQKKEVIFVTGIPGSGKTSTVKNMMMQDTTKLLFEGQLARPQSAFRKIEQCLERNLEVTIVA
VSMRAERASDNTYKRFNEYGREASIGIMADIQANLPDGLKQIRDKFGDAVKIVGINQDRNSEFIDKFDDVIKMLSLGSQE
QILGRLAEKIQSDFDSGKISRECFNQAKGSMDLESVFAKKEYSQQRVVTNSKGVTLETKSANELWSKVEQIPVTGMKAGI
YLLGQAKKAETGQTYSGEIIYKDAAAVFQKTKNGLVRHNATHNEERLAKLVEIGQNVSIGSNKGKLIVKSLEYSAKKSIS
R
MVKLSSDINLRDFGNNEYLSSVQDEAIRFATEQTDEILSLYSQHADTEGGRYVCADTFKELFPAFENKEDRATVNNAIHN
SAAVLSSTQFDEVLKRDEPQKKEVIFVTGIPGSGKTSTVKNMMMQDTTKLLFEGQLARPQSAFRKIEQCLERNLEVTIVA
VSMRAERASDNTYKRFNEYGREASIGIMADIQANLPDGLKQIRDKFGDAVKIVGINQDRNSEFIDKFDDVIKMLSLGSQE
QILGRLAEKIQSDFDSGKISRECFNQAKGSMDLESVFAKKEYSQQRVVTNSKGVTLETKSANELWSKVEQIPVTGMKAGI
YLLGQAKKAETGQTYSGEIIYKDAAAVFQKTKNGLVRHNATHNEERLAKLVEIGQNVSIGSNKGKLIVKSLEYSAKKSIS
R
Download Length: 1206 bp
Antitoxin
Download Length: 144 a.a. Molecular weight: 15927.05 Da Isoelectric Point: 4.4211
>AT259792 WP_003701903.1 NZ_CP106778:c18143-17712 [Neisseria gonorrhoeae]
MKEKMRLITEISLIIRELSYSRRGYRPESYAAALDNLTIIGDLADILHNIEAATGNPFVQRMVDEKLRKFVTDFPAYKVR
LSPFLNGCPHDLSLGAESLGKGESIADALAVPPEEVDIADIEFDRVLIEDDRWTGAYDGGNAQ
MKEKMRLITEISLIIRELSYSRRGYRPESYAAALDNLTIIGDLADILHNIEAATGNPFVQRMVDEKLRKFVTDFPAYKVR
LSPFLNGCPHDLSLGAESLGKGESIADALAVPPEEVDIADIEFDRVLIEDDRWTGAYDGGNAQ
Download Length: 432 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|