Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3430862..3431479 Replicon chromosome
Accession NC_016816
Organism Pantoea ananatis LMG 5342

Toxin (Protein)


Gene name Hha Uniprot ID D4GLR0
Locus tag PANA5342_RS38685 Protein ID WP_013024903.1
Coordinates 3431264..3431479 (+) Length 72 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A8A4KA49
Locus tag PANA5342_RS38680 Protein ID WP_015700827.1
Coordinates 3430862..3431239 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PANA5342_RS38650 3427147..3427401 + 255 WP_014606427.1 type B 50S ribosomal protein L31 -
PANA5342_RS38655 3427413..3427553 + 141 WP_014606428.1 type B 50S ribosomal protein L36 -
PANA5342_RS38660 3427613..3428491 - 879 WP_013024908.1 metal ABC transporter substrate-binding protein -
PANA5342_RS38665 3428504..3429343 - 840 WP_013024907.1 metal ABC transporter permease -
PANA5342_RS38670 3429340..3430008 - 669 WP_015700825.1 ABC transporter ATP-binding protein -
PANA5342_RS38675 3430362..3430715 + 354 WP_041455996.1 hypothetical protein -
PANA5342_RS38680 3430862..3431239 + 378 WP_015700827.1 Hha toxicity modulator TomB Antitoxin
PANA5342_RS38685 3431264..3431479 + 216 WP_013024903.1 hemolysin expression modulator Hha Toxin
PANA5342_RS38690 3431876..3432187 + 312 WP_015700828.1 MGMT family protein -
PANA5342_RS38695 3432236..3432793 - 558 WP_013024901.1 YbaY family lipoprotein -
PANA5342_RS38700 3432986..3433849 + 864 WP_015700830.1 acyl-CoA thioesterase II -
PANA5342_RS38705 3433896..3435185 - 1290 WP_014606435.1 ammonium transporter AmtB -
PANA5342_RS38710 3435219..3435557 - 339 WP_013024898.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(12-68)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 8552.98 Da        Isoelectric Point: 9.4825

>T25979 WP_013024903.1 NC_016816:3431264-3431479 [Pantoea ananatis LMG 5342]
MNKTLTKTDYLMRLRRCRSIDTLERVIEKNKYELPDEELAVFYSAADHRLAELTMNKLYDKVPVSVWKFVR

Download         Length: 216 bp

>T25979 NC_016816:3431264-3431479 [Pantoea ananatis LMG 5342]
ATGAACAAAACCCTAACTAAAACTGATTATTTGATGCGACTGAGGCGCTGTCGCTCTATTGACACGCTGGAACGCGTGAT
TGAAAAAAATAAGTACGAATTACCCGATGAAGAATTAGCAGTATTTTACTCAGCAGCCGATCACCGCCTGGCTGAACTGA
CGATGAACAAACTCTATGACAAAGTCCCGGTGTCAGTCTGGAAATTTGTACGCTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14722.35 Da        Isoelectric Point: 4.3976

>AT25979 WP_015700827.1 NC_016816:3430862-3431239 [Pantoea ananatis LMG 5342]
MDEYSPKRHDIAQLKYLCENLFDDSMATLTDSHHGWVNDPTAESNLQLNDLIEHIASFTMNYKIKHVEDEALITQIDEYL
DDTFMLFSNYSVNTQDLQRWQRSAKRLFNVFTEECAFLQQPSHSL

Download         Length: 378 bp

>AT25979 NC_016816:3430862-3431239 [Pantoea ananatis LMG 5342]
ATGGACGAATACTCACCGAAACGGCATGATATTGCCCAGCTTAAATACTTGTGTGAGAATCTGTTTGACGACAGCATGGC
GACATTAACTGACAGTCATCACGGCTGGGTTAATGACCCCACTGCCGAAAGCAATTTACAGCTAAACGATTTGATTGAGC
ACATCGCCTCTTTCACCATGAATTACAAAATTAAGCACGTTGAAGACGAAGCACTGATTACCCAAATCGATGAATATCTT
GATGATACTTTTATGCTGTTTAGCAACTACAGTGTAAATACTCAGGATCTTCAGCGCTGGCAACGCTCAGCGAAACGTTT
ATTTAATGTGTTTACTGAAGAGTGCGCTTTTCTTCAACAGCCAAGCCATTCATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References