Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 1069..1532 Replicon plasmid pJD1
Accession NZ_CP106774
Organism Neisseria gonorrhoeae strain 10562

Toxin (Protein)


Gene name VapD Uniprot ID Q51003
Locus tag LLE35_RS11730 Protein ID WP_003690225.1
Coordinates 1254..1532 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q51002
Locus tag LLE35_RS11725 Protein ID WP_003690223.1
Coordinates 1069..1254 (+) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLE35_RS11715 (LLE35_11625) 582..824 + 243 WP_003690220.1 HTH domain-containing protein -
LLE35_RS11720 (LLE35_11630) 821..1066 + 246 WP_003690221.1 hypothetical protein -
LLE35_RS11725 (LLE35_11635) 1069..1254 + 186 WP_003690223.1 DUF5397 family protein Antitoxin
LLE35_RS11730 (LLE35_11640) 1254..1532 + 279 WP_003690225.1 endoribonuclease VapD Toxin
LLE35_RS11735 (LLE35_11645) 1510..1764 - 255 WP_003690227.1 Cryptic plasmid protein A -
LLE35_RS11740 (LLE35_11650) 1811..2452 - 642 WP_003690229.1 MbeB family mobilization protein -
LLE35_RS11745 (LLE35_11655) 2536..3165 - 630 WP_003696452.1 relaxase/mobilization nuclease domain-containing protein -
LLE35_RS11750 (LLE35_11660) 3150..3455 - 306 WP_003706530.1 MobC family plasmid mobilization relaxosome protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..4207 4207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(2-60)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10473.89 Da        Isoelectric Point: 6.9726

>T259787 WP_003690225.1 NZ_CP106774:1254-1532 [Neisseria gonorrhoeae]
MYAISFDLVVADTAQNHPKGISQAYADIGYTLRKFGFTRIQGSLYTCQNEDMANLFSAINELKALPWFPSSVRDIRAFRI
EQWSDFTSLVKS

Download         Length: 279 bp

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 6717.54 Da        Isoelectric Point: 4.2641

>AT259787 WP_003690223.1 NZ_CP106774:1069-1254 [Neisseria gonorrhoeae]
MQTTIPTGSIRTFGDYGVMYIVGTPAEQLPDGDWLVNIELPESGEHTQYKLSHIVQDPKAA

Download         Length: 186 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H5FJI5

Antitoxin

Source ID Structure
AlphaFold DB Q51002

References