Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 657525..658180 Replicon chromosome
Accession NZ_CP106773
Organism Neisseria gonorrhoeae strain 10562

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LLE35_RS03545 Protein ID WP_229931500.1
Coordinates 657761..658180 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag LLE35_RS03540 Protein ID WP_003688410.1
Coordinates 657525..657761 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLE35_RS03510 (LLE35_03495) 652660..652947 + 288 WP_003688407.1 hypothetical protein -
LLE35_RS03515 (LLE35_03500) 653019..654185 + 1167 WP_003699872.1 ADP-forming succinate--CoA ligase subunit beta -
LLE35_RS03520 (LLE35_03505) 654196..655086 + 891 WP_229931474.1 succinate--CoA ligase subunit alpha -
LLE35_RS03525 (LLE35_03510) 655469..655855 - 387 Protein_688 transposase -
LLE35_RS03530 (LLE35_03515) 656094..656495 + 402 WP_020996834.1 helix-turn-helix domain-containing protein -
LLE35_RS03535 (LLE35_03520) 656500..657078 + 579 WP_003697246.1 IS3 family transposase -
LLE35_RS03540 (LLE35_03525) 657525..657761 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
LLE35_RS03545 (LLE35_03530) 657761..658180 + 420 WP_229931500.1 type II toxin-antitoxin system toxin FitB Toxin
LLE35_RS03550 (LLE35_03535) 658329..659783 - 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
LLE35_RS03555 (LLE35_03540) 659780..660481 - 702 WP_003688414.1 lactate utilization protein C -
LLE35_RS03560 (LLE35_03545) 660478..661257 - 780 WP_003688416.1 (Fe-S)-binding protein -
LLE35_RS03565 (LLE35_03550) 661405..662946 + 1542 WP_003691084.1 MDR family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15336.67 Da        Isoelectric Point: 5.5742

>T259785 WP_229931500.1 NZ_CP106773:657761-658180 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGWILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT259785 WP_003688410.1 NZ_CP106773:657525-657761 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References