Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 56..519 Replicon plasmid pJD1
Accession NZ_CP106770
Organism Neisseria gonorrhoeae strain 10524

Toxin (Protein)


Gene name VapD Uniprot ID Q51003
Locus tag LLE34_RS11750 Protein ID WP_003690225.1
Coordinates 56..334 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q51002
Locus tag LLE34_RS11755 Protein ID WP_003690223.1
Coordinates 334..519 (-) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLE34_RS11750 (LLE34_11750) 56..334 - 279 WP_003690225.1 endoribonuclease VapD Toxin
LLE34_RS11755 (LLE34_11755) 334..519 - 186 WP_003690223.1 DUF5397 family protein Antitoxin
LLE34_RS11760 (LLE34_11760) 522..767 - 246 WP_003690221.1 hypothetical protein -
LLE34_RS11765 (LLE34_11765) 764..1006 - 243 WP_003690220.1 HTH domain-containing protein -
LLE34_RS11770 (LLE34_11770) 1010..1879 - 870 WP_003690219.1 replication initiation protein -
LLE34_RS11775 (LLE34_11775) 1962..2186 - 225 WP_025455920.1 hypothetical protein -
LLE34_RS11780 (LLE34_11780) 2265..2645 + 381 WP_014580441.1 MobC family plasmid mobilization relaxosome protein -
LLE34_RS11785 (LLE34_11785) 2630..3259 + 630 WP_003696452.1 relaxase/mobilization nuclease domain-containing protein -
LLE34_RS11790 (LLE34_11790) 3343..3984 + 642 WP_003690229.1 MbeB family mobilization protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..4207 4207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(2-60)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10473.89 Da        Isoelectric Point: 6.9726

>T259782 WP_003690225.1 NZ_CP106770:c334-56 [Neisseria gonorrhoeae]
MYAISFDLVVADTAQNHPKGISQAYADIGYTLRKFGFTRIQGSLYTCQNEDMANLFSAINELKALPWFPSSVRDIRAFRI
EQWSDFTSLVKS

Download         Length: 279 bp

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 6717.54 Da        Isoelectric Point: 4.2641

>AT259782 WP_003690223.1 NZ_CP106770:c519-334 [Neisseria gonorrhoeae]
MQTTIPTGSIRTFGDYGVMYIVGTPAEQLPDGDWLVNIELPESGEHTQYKLSHIVQDPKAA

Download         Length: 186 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H5FJI5

Antitoxin

Source ID Structure
AlphaFold DB Q51002

References