Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 1099..1562 Replicon plasmid pjD1
Accession NZ_CP106766
Organism Neisseria gonorrhoeae strain 10500

Toxin (Protein)


Gene name VapD Uniprot ID Q51003
Locus tag LLE30_RS11700 Protein ID WP_003690225.1
Coordinates 1284..1562 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q51002
Locus tag LLE30_RS11695 Protein ID WP_003690223.1
Coordinates 1099..1284 (+) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLE30_RS11685 (LLE30_11685) 612..854 + 243 WP_003690220.1 HTH domain-containing protein -
LLE30_RS11690 (LLE30_11690) 851..1096 + 246 WP_003690221.1 hypothetical protein -
LLE30_RS11695 (LLE30_11695) 1099..1284 + 186 WP_003690223.1 DUF5397 family protein Antitoxin
LLE30_RS11700 (LLE30_11700) 1284..1562 + 279 WP_003690225.1 endoribonuclease VapD Toxin
LLE30_RS11705 (LLE30_11705) 1540..1794 - 255 WP_003690227.1 Cryptic plasmid protein A -
LLE30_RS11710 (LLE30_11710) 1841..2482 - 642 WP_003690229.1 MbeB family mobilization protein -
LLE30_RS11715 (LLE30_11715) 2566..3195 - 630 WP_003696452.1 relaxase/mobilization nuclease domain-containing protein -
LLE30_RS11720 (LLE30_11720) 3180..3560 - 381 WP_014580441.1 MobC family plasmid mobilization relaxosome protein -
LLE30_RS11725 (LLE30_11725) 3639..3863 + 225 WP_025455920.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..4207 4207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(2-60)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10473.89 Da        Isoelectric Point: 6.9726

>T259776 WP_003690225.1 NZ_CP106766:1284-1562 [Neisseria gonorrhoeae]
MYAISFDLVVADTAQNHPKGISQAYADIGYTLRKFGFTRIQGSLYTCQNEDMANLFSAINELKALPWFPSSVRDIRAFRI
EQWSDFTSLVKS

Download         Length: 279 bp

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 6717.54 Da        Isoelectric Point: 4.2641

>AT259776 WP_003690223.1 NZ_CP106766:1099-1284 [Neisseria gonorrhoeae]
MQTTIPTGSIRTFGDYGVMYIVGTPAEQLPDGDWLVNIELPESGEHTQYKLSHIVQDPKAA

Download         Length: 186 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H5FJI5

Antitoxin

Source ID Structure
AlphaFold DB Q51002

References