Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5364758..5365383 Replicon chromosome
Accession NZ_CP106760
Organism Klebsiella pneumoniae strain KP0937

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag N8627_RS26495 Protein ID WP_002882817.1
Coordinates 5364758..5365141 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag N8627_RS26500 Protein ID WP_004150355.1
Coordinates 5365141..5365383 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8627_RS26480 (N8627_26480) 5362124..5363026 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
N8627_RS26485 (N8627_26485) 5363023..5363658 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
N8627_RS26490 (N8627_26490) 5363655..5364584 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
N8627_RS26495 (N8627_26495) 5364758..5365141 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
N8627_RS26500 (N8627_26500) 5365141..5365383 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
N8627_RS26505 (N8627_26505) 5365588..5366505 + 918 WP_002882812.1 alpha/beta hydrolase -
N8627_RS26510 (N8627_26510) 5366519..5367460 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
N8627_RS26515 (N8627_26515) 5367505..5367942 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
N8627_RS26520 (N8627_26520) 5367939..5368799 - 861 WP_002882807.1 virulence factor BrkB family protein -
N8627_RS26525 (N8627_26525) 5368793..5369392 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T259762 WP_002882817.1 NZ_CP106760:c5365141-5364758 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT259762 WP_004150355.1 NZ_CP106760:c5365383-5365141 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References