Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5039507..5041188 Replicon chromosome
Accession NZ_CP106760
Organism Klebsiella pneumoniae strain KP0937

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag N8627_RS24980 Protein ID WP_002885155.1
Coordinates 5039507..5040424 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag N8627_RS24985 Protein ID WP_004151732.1
Coordinates 5040430..5041188 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8627_RS24960 (N8627_24960) 5034813..5036333 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
N8627_RS24965 (N8627_24965) 5036330..5037328 + 999 WP_002885172.1 ribose ABC transporter permease -
N8627_RS24970 (N8627_24970) 5037359..5038300 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
N8627_RS24975 (N8627_24975) 5038375..5039382 + 1008 WP_004151731.1 carbohydrate kinase family protein -
N8627_RS24980 (N8627_24980) 5039507..5040424 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
N8627_RS24985 (N8627_24985) 5040430..5041188 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
N8627_RS24990 (N8627_24990) 5041274..5042002 - 729 WP_002885152.1 response regulator transcription factor -
N8627_RS24995 (N8627_24995) 5042275..5044422 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
N8627_RS25000 (N8627_25000) 5044652..5045338 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T259761 WP_002885155.1 NZ_CP106760:c5040424-5039507 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT259761 WP_004151732.1 NZ_CP106760:c5041188-5040430 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References