Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2743325..2744913 Replicon chromosome
Accession NZ_CP106760
Organism Klebsiella pneumoniae strain KP0937

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag N8627_RS13625 Protein ID WP_004199851.1
Coordinates 2743325..2744647 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag N8627_RS13630 Protein ID WP_002904790.1
Coordinates 2744647..2744913 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8627_RS13610 (N8627_13610) 2738390..2740891 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
N8627_RS13615 (N8627_13615) 2740879..2741883 + 1005 WP_004199852.1 fimbrial protein -
N8627_RS13620 (N8627_13620) 2742016..2743308 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
N8627_RS13625 (N8627_13625) 2743325..2744647 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
N8627_RS13630 (N8627_13630) 2744647..2744913 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
N8627_RS13635 (N8627_13635) 2745179..2745505 - 327 WP_002904788.1 hydroxyisourate hydrolase -
N8627_RS13640 (N8627_13640) 2745502..2746002 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
N8627_RS13645 (N8627_13645) 2745980..2747359 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
N8627_RS13650 (N8627_13650) 2747705..2748859 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
N8627_RS13655 (N8627_13655) 2748840..2749763 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T259756 WP_004199851.1 NZ_CP106760:c2744647-2743325 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT259756 WP_002904790.1 NZ_CP106760:c2744913-2744647 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References