Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4033311..4034146 Replicon chromosome
Accession NZ_CP106756
Organism Escherichia coli strain B-JRPT-4119

Toxin (Protein)


Gene name yeeV Uniprot ID A0A376WVB1
Locus tag N8153_RS19640 Protein ID WP_001094448.1
Coordinates 4033769..4034146 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag N8153_RS19635 Protein ID WP_115914908.1
Coordinates 4033311..4033679 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8153_RS19610 (4028372) 4028372..4030732 + 2361 Protein_3815 Ag43/Cah family autotransporter adhesin -
N8153_RS19615 (4031060) 4031060..4031878 + 819 WP_072643846.1 DUF932 domain-containing protein -
N8153_RS19620 (4031970) 4031970..4032455 + 486 WP_000214415.1 antirestriction protein -
N8153_RS19625 (4032471) 4032471..4032947 + 477 WP_001186725.1 RadC family protein -
N8153_RS19630 (4033016) 4033016..4033237 + 222 WP_073544043.1 DUF987 domain-containing protein -
N8153_RS19635 (4033311) 4033311..4033679 + 369 WP_115914908.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
N8153_RS19640 (4033769) 4033769..4034146 + 378 WP_001094448.1 TA system toxin CbtA family protein Toxin
N8153_RS19645 (4034143) 4034143..4034631 + 489 WP_000761714.1 DUF5983 family protein -
N8153_RS19650 (4034643) 4034643..4034840 + 198 WP_001737717.1 DUF957 domain-containing protein -
N8153_RS19655 (4034925) 4034925..4035770 + 846 Protein_3824 DUF4942 domain-containing protein -
N8153_RS19660 (4035841) 4035841..4037376 + 1536 WP_021571439.1 EAL domain-containing protein -
N8153_RS19665 (4037773) 4037773..4037994 + 222 Protein_3826 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14221.22 Da        Isoelectric Point: 8.2919

>T259725 WP_001094448.1 NZ_CP106756:4033769-4034146 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13572.36 Da        Isoelectric Point: 6.2044

>AT259725 WP_115914908.1 NZ_CP106756:4033311-4033679 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A376WVB1

Antitoxin

Source ID Structure

References