Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3922384..3923038 Replicon chromosome
Accession NZ_CP106756
Organism Escherichia coli strain B-JRPT-4119

Toxin (Protein)


Gene name cptA Uniprot ID A0A140N853
Locus tag N8153_RS19085 Protein ID WP_000244783.1
Coordinates 3922384..3922791 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag N8153_RS19090 Protein ID WP_000354046.1
Coordinates 3922772..3923038 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8153_RS19065 (3918341) 3918341..3920074 - 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -
N8153_RS19070 (3920080) 3920080..3920790 - 711 WP_000715216.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N8153_RS19075 (3920815) 3920815..3921711 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
N8153_RS19080 (3921823) 3921823..3922344 + 522 WP_001055874.1 flavodoxin FldB -
N8153_RS19085 (3922384) 3922384..3922791 - 408 WP_000244783.1 protein YgfX Toxin
N8153_RS19090 (3922772) 3922772..3923038 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
N8153_RS19095 (3923281) 3923281..3924261 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
N8153_RS19100 (3924457) 3924457..3925116 - 660 WP_000250274.1 hemolysin III family protein -
N8153_RS19105 (3925280) 3925280..3925591 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
N8153_RS19110 (3925636) 3925636..3927069 + 1434 WP_263082296.1 6-phospho-beta-glucosidase BglA -
N8153_RS19115 (3927126) 3927126..3927869 - 744 WP_000951948.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15962.85 Da        Isoelectric Point: 11.2669

>T259724 WP_000244783.1 NZ_CP106756:c3922791-3922384 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEISLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT259724 WP_000354046.1 NZ_CP106756:c3923038-3922772 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A140N853

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References