Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3796676..3797259 Replicon chromosome
Accession NZ_CP106756
Organism Escherichia coli strain B-JRPT-4119

Toxin (Protein)


Gene name mazF Uniprot ID A0A1V3W215
Locus tag N8153_RS18565 Protein ID WP_000254741.1
Coordinates 3796676..3797011 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S1P3W5
Locus tag N8153_RS18570 Protein ID WP_000581937.1
Coordinates 3797011..3797259 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8153_RS18550 (3792563) 3792563..3793861 - 1299 WP_000036723.1 phosphopyruvate hydratase -
N8153_RS18555 (3793949) 3793949..3795586 - 1638 WP_000210878.1 CTP synthase (glutamine hydrolyzing) -
N8153_RS18560 (3795814) 3795814..3796605 - 792 WP_001071648.1 nucleoside triphosphate pyrophosphohydrolase -
N8153_RS18565 (3796676) 3796676..3797011 - 336 WP_000254741.1 endoribonuclease MazF Toxin
N8153_RS18570 (3797011) 3797011..3797259 - 249 WP_000581937.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
N8153_RS18575 (3797337) 3797337..3799571 - 2235 WP_000226815.1 GTP pyrophosphokinase -
N8153_RS18580 (3799619) 3799619..3800920 - 1302 WP_000046810.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12114.04 Da        Isoelectric Point: 8.2618

>T259723 WP_000254741.1 NZ_CP106756:c3797011-3796676 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGSTKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9355.74 Da        Isoelectric Point: 4.4665

>AT259723 WP_000581937.1 NZ_CP106756:c3797259-3797011 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1V3W215

Antitoxin

Source ID Structure
PDB 1UB4
PDB 5CQX
PDB 5CQY
PDB 1MVF
PDB 2MRN
PDB 2MRU
AlphaFold DB A0A7U9LMB4

References