Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2393236..2393874 Replicon chromosome
Accession NZ_CP106756
Organism Escherichia coli strain B-JRPT-4119

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag N8153_RS11650 Protein ID WP_000813794.1
Coordinates 2393236..2393412 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N8153_RS11655 Protein ID WP_001270286.1
Coordinates 2393458..2393874 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8153_RS11630 (2388855) 2388855..2390069 - 1215 WP_001326689.1 BenE family transporter YdcO -
N8153_RS11635 (2390122) 2390122..2390658 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
N8153_RS11640 (2390731) 2390731..2392692 + 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
N8153_RS11645 (2392784) 2392784..2393014 - 231 WP_000494244.1 YncJ family protein -
N8153_RS11650 (2393236) 2393236..2393412 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
N8153_RS11655 (2393458) 2393458..2393874 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
N8153_RS11660 (2393953) 2393953..2395359 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
N8153_RS11665 (2395604) 2395604..2396749 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
N8153_RS11670 (2396767) 2396767..2397780 + 1014 WP_000220415.1 ABC transporter ATP-binding protein -
N8153_RS11675 (2397781) 2397781..2398722 + 942 WP_001251313.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T259715 WP_000813794.1 NZ_CP106756:2393236-2393412 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT259715 WP_001270286.1 NZ_CP106756:2393458-2393874 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References