Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1405889..1406507 Replicon chromosome
Accession NZ_CP106756
Organism Escherichia coli strain B-JRPT-4119

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N8153_RS06755 Protein ID WP_001291435.1
Coordinates 1405889..1406107 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N8153_RS06760 Protein ID WP_000344800.1
Coordinates 1406133..1406507 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8153_RS06720 (1401178) 1401178..1401750 + 573 WP_000779826.1 YbaY family lipoprotein -
N8153_RS06725 (1401781) 1401781..1402092 - 312 WP_000409911.1 MGMT family protein -
N8153_RS06735 (1402471) 1402471..1402824 + 354 WP_000878140.1 DUF1428 domain-containing protein -
N8153_RS06740 (1402866) 1402866..1404416 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N8153_RS06745 (1404580) 1404580..1405050 - 471 WP_001301147.1 YlaC family protein -
N8153_RS06750 (1405166) 1405166..1405717 - 552 WP_000102564.1 maltose O-acetyltransferase -
N8153_RS06755 (1405889) 1405889..1406107 - 219 WP_001291435.1 HHA domain-containing protein Toxin
N8153_RS06760 (1406133) 1406133..1406507 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N8153_RS06765 (1407053) 1407053..1410202 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
N8153_RS06770 (1410225) 1410225..1411418 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T259714 WP_001291435.1 NZ_CP106756:c1406107-1405889 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT259714 WP_000344800.1 NZ_CP106756:c1406507-1406133 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References