Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 634397..634894 Replicon chromosome
Accession NZ_CP106756
Organism Escherichia coli strain B-JRPT-4119

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag N8153_RS02935 Protein ID WP_001173343.1
Coordinates 634721..634894 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag N8153_RS02930 Protein ID WP_000398619.1
Coordinates 634397..634693 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8153_RS02910 (631128) 631128..631847 - 720 WP_000611288.1 two-component system response regulator DcuR -
N8153_RS02915 (631844) 631844..633475 - 1632 WP_001216477.1 sensor histidine kinase -
N8153_RS02920 (633656) 633656..633886 + 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
N8153_RS02925 (633898) 633898..634170 + 273 WP_000405651.1 GNAT family N-acetyltransferase -
N8153_RS02930 (634397) 634397..634693 + 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
N8153_RS02935 (634721) 634721..634894 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
N8153_RS02940 (635013) 635013..636530 - 1518 WP_001295090.1 lysine--tRNA ligase -
N8153_RS02945 (636767) 636767..638224 - 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T259708 WP_001173343.1 NZ_CP106756:634721-634894 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT259708 WP_000398619.1 NZ_CP106756:634397-634693 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References