Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 4566651..4567288 Replicon chromosome
Accession NZ_CP106754
Organism Kosakonia sp. ML.JS2a

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag N7922_RS21560 Protein ID WP_263098199.1
Coordinates 4566651..4566821 (+) Length 57 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N7922_RS21565 Protein ID WP_263098200.1
Coordinates 4566851..4567288 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7922_RS21550 (N7922_21550) 4564000..4565364 + 1365 WP_263098197.1 efflux transporter outer membrane subunit -
N7922_RS21555 (N7922_21555) 4565411..4566574 + 1164 WP_263098198.1 multidrug effflux MFS transporter -
N7922_RS21560 (N7922_21560) 4566651..4566821 + 171 WP_263098199.1 type II toxin-antitoxin system HicA family toxin Toxin
N7922_RS21565 (N7922_21565) 4566851..4567288 + 438 WP_263098200.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N7922_RS21570 (N7922_21570) 4567285..4568178 - 894 WP_263098201.1 MurR/RpiR family transcriptional regulator -
N7922_RS21575 (N7922_21575) 4568190..4569137 - 948 WP_263098202.1 iron-siderophore ABC transporter substrate-binding protein -
N7922_RS21580 (N7922_21580) 4569153..4570205 - 1053 WP_263098203.1 iron ABC transporter permease -
N7922_RS21585 (N7922_21585) 4570202..4571179 - 978 WP_263100974.1 iron ABC transporter permease -
N7922_RS21590 (N7922_21590) 4571224..4572051 - 828 WP_263098204.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(16-55)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-82)


Sequences

Toxin        


Download         Length: 57 a.a.        Molecular weight: 6392.65 Da        Isoelectric Point: 11.0962

>T259707 WP_263098199.1 NZ_CP106754:4566651-4566821 [Kosakonia sp. ML.JS2a]
MKYSEFRKWLLLIKAPGGGSHFKVKLNGRASVFPFHGSKEIPEPLRKKILKDLGLQ

Download         Length: 171 bp

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 15926.27 Da        Isoelectric Point: 4.7503

>AT259707 WP_263098200.1 NZ_CP106754:4566851-4567288 [Kosakonia sp. ML.JS2a]
MFNYPVSVEQDDVTGQFVVSCRDLPLMNSVGDTLDDALLQSVDAMVVAIAIEVDERRPIPQASAALPGEYVVSLPVLVAM
KAALHNAMIETGTRKAELARKLGQKGPQIDRLLDVEHSSKVETVELALHQLNRQIDLTITQQHRT

Download         Length: 438 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References