Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 4530661..4531225 Replicon chromosome
Accession NZ_CP106754
Organism Kosakonia sp. ML.JS2a

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag N7922_RS21390 Protein ID WP_263098168.1
Coordinates 4530661..4530969 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1C4A1Z8
Locus tag N7922_RS21395 Protein ID WP_061497949.1
Coordinates 4530953..4531225 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7922_RS21365 (N7922_21365) 4526750..4527217 - 468 WP_061497942.1 YjiG family protein -
N7922_RS21370 (N7922_21370) 4527210..4527893 - 684 WP_263098164.1 nucleoside recognition domain-containing protein -
N7922_RS21375 (N7922_21375) 4528271..4529167 + 897 WP_263098165.1 LysR substrate-binding domain-containing protein -
N7922_RS21380 (N7922_21380) 4529211..4529981 + 771 WP_263098166.1 AraC family transcriptional regulator -
N7922_RS21385 (N7922_21385) 4530032..4530655 + 624 WP_263098167.1 LysE family translocator -
N7922_RS21390 (N7922_21390) 4530661..4530969 - 309 WP_263098168.1 type II toxin-antitoxin system YafQ family toxin Toxin
N7922_RS21395 (N7922_21395) 4530953..4531225 - 273 WP_061497949.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N7922_RS21400 (N7922_21400) 4531311..4532591 + 1281 WP_263098169.1 DUF445 domain-containing protein -
N7922_RS21405 (N7922_21405) 4532612..4532851 + 240 WP_263098170.1 DUF2164 domain-containing protein -
N7922_RS21410 (N7922_21410) 4532974..4534125 + 1152 WP_263098171.1 double-cubane-cluster-containing anaerobic reductase -
N7922_RS21415 (N7922_21415) 4534135..4534905 + 771 WP_263098172.1 putative 2-hydroxyacyl-CoA dehydratase activator YjiL -
N7922_RS21420 (N7922_21420) 4534898..4535134 + 237 WP_263098173.1 DUF3343 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(15-101)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-66)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11532.21 Da        Isoelectric Point: 8.0942

>T259706 WP_263098168.1 NZ_CP106754:c4530969-4530661 [Kosakonia sp. ML.JS2a]
MMGKSKRAPLPYRSDYTKTFVKAWARYNKAGRRDMHETAAIMSMVLSGNPLPAQYSDHALTGNMHGFRELHPGGDYLLVY
CVDEAKHLVVFTDLGTHAELFE

Download         Length: 309 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10072.40 Da        Isoelectric Point: 6.4632

>AT259706 WP_061497949.1 NZ_CP106754:c4531225-4530953 [Kosakonia sp. ML.JS2a]
MDSVIRSRIDSELKARAGLVLESCGLNWSTAIRLFAEQIVKSEGIPFEVTRKPTARLRNAMSEANEITTHQHGRFNGVEQ
LMDSLNDGKE

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1C4A1Z8

References