Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3984794..3985410 Replicon chromosome
Accession NZ_CP106754
Organism Kosakonia sp. ML.JS2a

Toxin (Protein)


Gene name Hha Uniprot ID A0A1C4ALL4
Locus tag N7922_RS18870 Protein ID WP_061497097.1
Coordinates 3985192..3985410 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A1C4ALI7
Locus tag N7922_RS18865 Protein ID WP_061497094.1
Coordinates 3984794..3985168 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7922_RS18855 (N7922_18855) 3979915..3981108 + 1194 WP_263097758.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N7922_RS18860 (N7922_18860) 3981131..3984280 + 3150 WP_263097759.1 multidrug efflux RND transporter permease subunit AcrB -
N7922_RS18865 (N7922_18865) 3984794..3985168 + 375 WP_061497094.1 Hha toxicity modulator TomB Antitoxin
N7922_RS18870 (N7922_18870) 3985192..3985410 + 219 WP_061497097.1 HHA domain-containing protein Toxin
N7922_RS18875 (N7922_18875) 3985485..3986051 + 567 WP_263097760.1 maltose O-acetyltransferase -
N7922_RS18880 (N7922_18880) 3986152..3986631 + 480 WP_263097761.1 YlaC family protein -
N7922_RS18885 (N7922_18885) 3986597..3988045 - 1449 WP_263097762.1 PLP-dependent aminotransferase family protein -
N7922_RS18890 (N7922_18890) 3988144..3988845 + 702 WP_263097763.1 GNAT family protein -
N7922_RS18895 (N7922_18895) 3988842..3988982 - 141 WP_088236752.1 type B 50S ribosomal protein L36 -
N7922_RS18900 (N7922_18900) 3988986..3989246 - 261 WP_061497109.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8627.01 Da        Isoelectric Point: 7.9892

>T259705 WP_061497097.1 NZ_CP106754:3985192-3985410 [Kosakonia sp. ML.JS2a]
MSEKPLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDDELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14486.34 Da        Isoelectric Point: 5.8926

>AT259705 WP_061497094.1 NZ_CP106754:3984794-3985168 [Kosakonia sp. ML.JS2a]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESHHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKTGNKLFRCFVNVSKANPVSHSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C4ALL4

Antitoxin

Source ID Structure
AlphaFold DB A0A1C4ALI7

References