Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4333703..4334961 Replicon chromosome
Accession NZ_CP106745
Organism Pseudomonas aeruginosa strain PALA17

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag PALA17_RS20310 Protein ID WP_012614407.1
Coordinates 4333703..4334458 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA17_RS20315 Protein ID WP_003086329.1
Coordinates 4334593..4334961 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA17_RS20300 (PALA17_04039) 4328876..4331419 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
PALA17_RS20305 (PALA17_04040) 4331574..4332935 - 1362 WP_003081943.1 DNA recombination protein RmuC -
PALA17_RS20310 (PALA17_04041) 4333703..4334458 - 756 WP_012614407.1 RES family NAD+ phosphorylase Toxin
PALA17_RS20315 (PALA17_04042) 4334593..4334961 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA17_RS20320 (PALA17_04043) 4335034..4336320 - 1287 WP_012614408.1 FAD-binding oxidoreductase -
PALA17_RS20325 (PALA17_04044) 4336376..4337965 - 1590 WP_003125055.1 aldehyde dehydrogenase family protein -
PALA17_RS20330 (PALA17_04045) 4338044..4338520 + 477 WP_003112531.1 hypothetical protein -
PALA17_RS20335 4338523..4338798 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(63-207)

Antitoxin

(23-47)


Sequences


Toxin        


Download         Length: 252 a.a.        Molecular weight: 28250.37 Da        Isoelectric Point: 7.7294

>T259686 WP_012614407.1 NZ_CP106745:c4334458-4333703 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp


Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT259686 WP_003086329.1 NZ_CP106745:c4334961-4334593 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References