Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1658645..1660153 Replicon chromosome
Accession NZ_CP106745
Organism Pseudomonas aeruginosa strain PALA17

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag PALA17_RS07985 Protein ID WP_012613851.1
Coordinates 1658645..1659232 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag PALA17_RS07990 Protein ID WP_012613852.1
Coordinates 1659299..1660153 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA17_RS07980 (PALA17_01581) 1654900..1658379 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
PALA17_RS07985 (PALA17_01582) 1658645..1659232 + 588 WP_012613851.1 GNAT family protein Toxin
PALA17_RS07990 (PALA17_01583) 1659299..1660153 + 855 WP_012613852.1 AraC family transcriptional regulator Antitoxin
PALA17_RS07995 (PALA17_01584) 1660250..1662415 + 2166 WP_003091606.1 TonB-dependent receptor family protein -
PALA17_RS08000 (PALA17_01585) 1662590..1664464 + 1875 WP_003158329.1 MFS transporter -
PALA17_RS08005 (PALA17_01586) 1664525..1664734 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21929.29 Da        Isoelectric Point: 9.8676

>T259683 WP_012613851.1 NZ_CP106745:1658645-1659232 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAVLEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31959.27 Da        Isoelectric Point: 7.3276

>AT259683 WP_012613852.1 NZ_CP106745:1659299-1660153 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHADSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLPVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References