Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 114433..114938 Replicon chromosome
Accession NZ_CP106745
Organism Pseudomonas aeruginosa strain PALA17

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PALA17_RS00525 Protein ID WP_003083773.1
Coordinates 114657..114938 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PALA17_RS00520 Protein ID WP_003083775.1
Coordinates 114433..114660 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA17_RS00495 (PALA17_00100) 109451..110944 + 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
PALA17_RS00500 (PALA17_00101) 111113..112540 + 1428 WP_003083784.1 GABA permease -
PALA17_RS00505 (PALA17_00102) 112622..112963 - 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
PALA17_RS00510 (PALA17_00103) 113036..113536 - 501 WP_003101228.1 LEA type 2 family protein -
PALA17_RS00515 (PALA17_00104) 113637..114257 + 621 WP_003101226.1 hypothetical protein -
PALA17_RS00520 (PALA17_00105) 114433..114660 + 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PALA17_RS00525 (PALA17_00106) 114657..114938 + 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PALA17_RS00530 (PALA17_00107) 115238..116146 + 909 WP_012613448.1 LysR family transcriptional regulator -
PALA17_RS00535 (PALA17_00108) 116178..116588 - 411 WP_003101225.1 aegerolysin family protein -
PALA17_RS00540 (PALA17_00109) 116768..117502 - 735 WP_003117208.1 GntR family transcriptional regulator -
PALA17_RS00545 (PALA17_00110) 117603..118289 - 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
PALA17_RS00550 (PALA17_00111) 118338..119687 - 1350 WP_012613447.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T259681 WP_003083773.1 NZ_CP106745:114657-114938 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT259681 WP_003083775.1 NZ_CP106745:114433-114660 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References