259679

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 5586761..5587347 Replicon chromosome
Accession NZ_CP106744
Organism Pseudomonas aeruginosa strain PALA16

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag PALA16_RS26235 Protein ID WP_003120987.1
Coordinates 5587048..5587347 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag PALA16_RS26230 Protein ID WP_003448662.1
Coordinates 5586761..5587051 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA16_RS26205 (PALA16_05200) 5581912..5582121 + 210 WP_003105733.1 cold-shock protein -
PALA16_RS26210 (PALA16_05201) 5582343..5584232 + 1890 WP_016851610.1 hypothetical protein -
PALA16_RS26215 (PALA16_05202) 5584229..5586205 + 1977 WP_016851611.1 DEAD/DEAH box helicase -
PALA16_RS26220 5586215..5586349 + 135 WP_255253641.1 hypothetical protein -
PALA16_RS26225 5586346..5586690 + 345 WP_016851612.1 hypothetical protein -
PALA16_RS26230 (PALA16_05203) 5586761..5587051 - 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
PALA16_RS26235 (PALA16_05204) 5587048..5587347 - 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA16_RS26240 (PALA16_05205) 5587549..5588673 + 1125 WP_012076859.1 TcpQ domain-containing protein -
PALA16_RS26245 (PALA16_05206) 5588673..5590382 + 1710 WP_012076860.1 PilN family type IVB pilus formation outer membrane protein -
PALA16_RS26250 (PALA16_05207) 5590386..5591711 + 1326 WP_003099758.1 type 4b pilus protein PilO2 -
PALA16_RS26255 (PALA16_05208) 5591701..5592234 + 534 WP_003099760.1 type IV pilus biogenesis protein PilP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5560238..5663860 103622


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T259679 WP_003120987.1 NZ_CP106744:c5587347-5587048 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT259679 WP_003448662.1 NZ_CP106744:c5587051-5586761 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References