259678

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5190219..5190827 Replicon chromosome
Accession NZ_CP106744
Organism Pseudomonas aeruginosa strain PALA16

Toxin (Protein)


Gene name PfiT Uniprot ID A0A1B1XUZ2
Locus tag PALA16_RS24385 Protein ID WP_003123043.1
Coordinates 5190219..5190566 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag PALA16_RS24390 Protein ID WP_003114155.1
Coordinates 5190576..5190827 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA16_RS24355 (PALA16_04832) 5185578..5185850 + 273 WP_016851967.1 cysteine-rich CWC family protein -
PALA16_RS24360 (PALA16_04833) 5185850..5186542 + 693 WP_016851968.1 16S rRNA pseudouridine(516) synthase -
PALA16_RS24365 (PALA16_04834) 5186678..5187721 + 1044 WP_003098363.1 L,D-transpeptidase -
PALA16_RS24370 (PALA16_04835) 5187801..5188538 + 738 WP_003085453.1 murein L,D-transpeptidase catalytic domain family protein -
PALA16_RS24375 (PALA16_04836) 5188990..5189892 + 903 WP_014603238.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
PALA16_RS24385 (PALA16_04838) 5190219..5190566 - 348 WP_003123043.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA16_RS24390 5190576..5190827 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PALA16_RS24395 (PALA16_04839) 5191041..5192024 - 984 WP_016852062.1 tyrosine-type recombinase/integrase -
PALA16_RS24400 (PALA16_04840) 5192024..5193316 - 1293 WP_269972860.1 hypothetical protein -
PALA16_RS24405 (PALA16_04842) 5193575..5194836 - 1262 Protein_4829 hypothetical protein -
PALA16_RS24410 (PALA16_04844) 5194838..5195188 - 351 WP_003159569.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 5190219..5212060 21841


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12990.74 Da        Isoelectric Point: 4.4212

>T259678 WP_003123043.1 NZ_CP106744:c5190566-5190219 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT259678 WP_003114155.1 NZ_CP106744:c5190827-5190576 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1XUZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References