Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4829935..4831193 Replicon chromosome
Accession NZ_CP106744
Organism Pseudomonas aeruginosa strain PALA16

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag PALA16_RS22645 Protein ID WP_003112528.1
Coordinates 4829935..4830690 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA16_RS22650 Protein ID WP_003086329.1
Coordinates 4830825..4831193 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA16_RS22635 (PALA16_04491) 4825108..4827651 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
PALA16_RS22640 (PALA16_04492) 4827806..4829167 - 1362 WP_073647918.1 DNA recombination protein RmuC -
PALA16_RS22645 (PALA16_04493) 4829935..4830690 - 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
PALA16_RS22650 (PALA16_04494) 4830825..4831193 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA16_RS22655 (PALA16_04495) 4831266..4832552 - 1287 WP_003112529.1 FAD-binding oxidoreductase -
PALA16_RS22660 (PALA16_04496) 4832608..4834197 - 1590 WP_003125055.1 aldehyde dehydrogenase family protein -
PALA16_RS22665 (PALA16_04497) 4834276..4834752 + 477 WP_003112531.1 hypothetical protein -
PALA16_RS22670 4834755..4835030 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T259677 WP_003112528.1 NZ_CP106744:c4830690-4829935 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT259677 WP_003086329.1 NZ_CP106744:c4831193-4830825 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References