Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 3902318..3903539 | Replicon | chromosome |
| Accession | NZ_CP106744 | ||
| Organism | Pseudomonas aeruginosa strain PALA16 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | PALA16_RS18270 | Protein ID | WP_003114949.1 |
| Coordinates | 3902961..3903539 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | PALA16_RS18265 | Protein ID | WP_269972830.1 |
| Coordinates | 3902318..3902872 (+) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PALA16_RS18240 (PALA16_03612) | 3897886..3898437 | + | 552 | WP_003102727.1 | XRE family transcriptional regulator | - |
| PALA16_RS18245 (PALA16_03613) | 3898434..3898832 | - | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
| PALA16_RS18250 (PALA16_03614) | 3898845..3899168 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| PALA16_RS18255 (PALA16_03615) | 3899499..3899960 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| PALA16_RS18260 (PALA16_03616) | 3899965..3902160 | + | 2196 | WP_004349295.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| PALA16_RS18265 (PALA16_03617) | 3902318..3902872 | + | 555 | WP_269972830.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| PALA16_RS18270 (PALA16_03618) | 3902961..3903539 | + | 579 | WP_003114949.1 | HD domain-containing protein | Toxin |
| PALA16_RS18275 (PALA16_03619) | 3903647..3904834 | - | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| PALA16_RS18280 (PALA16_03620) | 3904824..3906995 | - | 2172 | WP_016851733.1 | type I secretion system permease/ATPase | - |
| PALA16_RS18285 (PALA16_03621) | 3906985..3908262 | - | 1278 | WP_003102743.1 | TolC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21897.75 Da Isoelectric Point: 5.3655
>T259676 WP_003114949.1 NZ_CP106744:3902961-3903539 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20420.61 Da Isoelectric Point: 8.1590
>AT259676 WP_269972830.1 NZ_CP106744:3902318-3902872 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALELASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALELASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|