259674

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2808353..2809395 Replicon chromosome
Accession NZ_CP106744
Organism Pseudomonas aeruginosa strain PALA16

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag PALA16_RS13260 Protein ID WP_003153636.1
Coordinates 2808820..2809395 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag PALA16_RS13255 Protein ID WP_003050245.1
Coordinates 2808353..2808823 (+) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA16_RS13220 (PALA16_02638) 2803744..2805162 - 1419 WP_003116808.1 TIGR03752 family integrating conjugative element protein -
PALA16_RS13225 (PALA16_02639) 2805152..2806063 - 912 WP_034022488.1 TIGR03749 family integrating conjugative element protein -
PALA16_RS13230 (PALA16_02640) 2806060..2806752 - 693 WP_004350603.1 TIGR03746 family integrating conjugative element protein -
PALA16_RS13235 (PALA16_02641) 2806749..2807147 - 399 WP_003153632.1 TIGR03750 family conjugal transfer protein -
PALA16_RS13240 (PALA16_02642) 2807160..2807519 - 360 WP_003153634.1 TIGR03745 family integrating conjugative element membrane protein -
PALA16_RS13245 (PALA16_02643) 2807536..2807769 - 234 WP_003050225.1 TIGR03758 family integrating conjugative element protein -
PALA16_RS13250 (PALA16_02644) 2807766..2808149 - 384 WP_003090167.1 RAQPRD family integrative conjugative element protein -
PALA16_RS13255 (PALA16_02645) 2808353..2808823 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
PALA16_RS13260 (PALA16_02646) 2808820..2809395 + 576 WP_003153636.1 PIN domain-containing protein Toxin
PALA16_RS13265 (PALA16_02647) 2809413..2810327 + 915 WP_003050256.1 AAA family ATPase -
PALA16_RS13270 (PALA16_02648) 2810324..2810794 + 471 WP_003153638.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
PALA16_RS13275 (PALA16_02649) 2810791..2811291 + 501 WP_003090159.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
PALA16_RS13280 (PALA16_02650) 2811291..2812193 + 903 WP_003153640.1 CBASS oligonucleotide cyclase -
PALA16_RS13285 (PALA16_02651) 2812232..2812957 + 726 WP_003050273.1 CBASS effector endonuclease NucC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2753974..2858931 104957


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T259674 WP_003153636.1 NZ_CP106744:2808820-2809395 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT259674 WP_003050245.1 NZ_CP106744:2808353-2808823 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References