Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1852259..1853767 Replicon chromosome
Accession NZ_CP106744
Organism Pseudomonas aeruginosa strain PALA16

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag PALA16_RS08585 Protein ID WP_269972950.1
Coordinates 1852259..1852846 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A5B3ABU1
Locus tag PALA16_RS08590 Protein ID WP_003119683.1
Coordinates 1852913..1853767 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA16_RS08580 (PALA16_01708) 1848514..1851993 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
PALA16_RS08585 (PALA16_01709) 1852259..1852846 + 588 WP_269972950.1 GNAT family protein Toxin
PALA16_RS08590 (PALA16_01710) 1852913..1853767 + 855 WP_003119683.1 AraC family transcriptional regulator Antitoxin
PALA16_RS08595 (PALA16_01711) 1853864..1856029 + 2166 WP_016852624.1 TonB-dependent receptor family protein -
PALA16_RS08600 (PALA16_01712) 1856204..1858078 + 1875 WP_003117607.1 MFS transporter -
PALA16_RS08605 (PALA16_01713) 1858139..1858348 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21913.29 Da        Isoelectric Point: 9.8676

>T259673 WP_269972950.1 NZ_CP106744:1852259-1852846 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFIG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31875.19 Da        Isoelectric Point: 7.5295

>AT259673 WP_003119683.1 NZ_CP106744:1852913-1853767 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5B3ABU1

References