Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4496595..4497853 Replicon chromosome
Accession NZ_CP106743
Organism Pseudomonas aeruginosa strain PALA15

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag PALA15_RS20675 Protein ID WP_003163133.1
Coordinates 4496595..4497350 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA15_RS20680 Protein ID WP_003086329.1
Coordinates 4497485..4497853 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA15_RS20665 (PALA15_04105) 4491767..4494310 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
PALA15_RS20670 (PALA15_04106) 4494465..4495826 - 1362 WP_079385385.1 DNA recombination protein RmuC -
PALA15_RS20675 (PALA15_04107) 4496595..4497350 - 756 WP_003163133.1 RES family NAD+ phosphorylase Toxin
PALA15_RS20680 (PALA15_04108) 4497485..4497853 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA15_RS20685 (PALA15_04109) 4497926..4499212 - 1287 WP_003163134.1 FAD-binding oxidoreductase -
PALA15_RS20690 (PALA15_04110) 4499268..4500857 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
PALA15_RS20695 (PALA15_04111) 4500936..4501412 + 477 WP_003140638.1 hypothetical protein -
PALA15_RS20700 4501415..4501690 - 276 WP_010792073.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28250.37 Da        Isoelectric Point: 7.7294

>T259670 WP_003163133.1 NZ_CP106743:c4497350-4496595 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT259670 WP_003086329.1 NZ_CP106743:c4497853-4497485 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References