Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 3584466..3585687 | Replicon | chromosome |
| Accession | NZ_CP106743 | ||
| Organism | Pseudomonas aeruginosa strain PALA15 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | PALA15_RS16375 | Protein ID | WP_003114949.1 |
| Coordinates | 3585109..3585687 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | PALA15_RS16370 | Protein ID | WP_003088112.1 |
| Coordinates | 3584466..3585020 (+) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PALA15_RS16345 (PALA15_03241) | 3580034..3580585 | + | 552 | WP_003132721.1 | XRE family transcriptional regulator | - |
| PALA15_RS16350 (PALA15_03242) | 3580582..3580980 | - | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
| PALA15_RS16355 (PALA15_03243) | 3580993..3581316 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| PALA15_RS16360 (PALA15_03244) | 3581647..3582108 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| PALA15_RS16365 (PALA15_03245) | 3582113..3584308 | + | 2196 | WP_004349295.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| PALA15_RS16370 (PALA15_03246) | 3584466..3585020 | + | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| PALA15_RS16375 (PALA15_03247) | 3585109..3585687 | + | 579 | WP_003114949.1 | HD domain-containing protein | Toxin |
| PALA15_RS16380 (PALA15_03248) | 3585795..3586982 | - | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| PALA15_RS16385 (PALA15_03249) | 3586972..3589143 | - | 2172 | WP_016851733.1 | type I secretion system permease/ATPase | - |
| PALA15_RS16390 (PALA15_03250) | 3589133..3590410 | - | 1278 | WP_003102743.1 | TolC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21897.75 Da Isoelectric Point: 5.3655
>T259669 WP_003114949.1 NZ_CP106743:3585109-3585687 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT259669 WP_003088112.1 NZ_CP106743:3584466-3585020 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|